It highlighted Derek and Meredith's breakup, segued into his romance with Rose, and featured enough drama surrounding other characters to keep viewers tuning in to every episode. Each of the residents is assigned interns. Cristina is assigned Lexie Grey, Meredith's half-sister, who desperately wants to get to know Meredith. Derek tells Cristina that Burke put in his resignation two weeks prior. Derek and Meredith meet up, and she says that it's over between them. Of course, they seal the deal with a bit of breakup sex.
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Most notably, the season kicks off with Dr. Burke nowhere to be found. Isaiah Washington was written off the show at the end of season three after he admittedly used homophobic language referring to co-star T. Knight, while on set. The audience also got to meet a few new characters in season four, with Dr.
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TV Schedule. Sign In. Grey's Anatomy —. S4, Ep1. Error: please try again. The interns, now residents, deal with their own crops of interns. Callie struggles with her new position, and Burke makes a decision.