Testosterone is a male sex hormone that is important for sexual and reproductive development. The National Institutes of Health regards testosterone as the most important male hormone. Women also produce testosterone, but at lower levels than men. Testosterone belongs to a class of male hormones called androgens, which are sometimes called steroids or anabolic steroids. In men, testosterone is produced mainly in the testes, with a small amount made in the adrenal glands. The brain's hypothalamus and pituitary gland control testosterone production. The hypothalamus instructs the pituitary gland on how much testosterone to produce, and the pituitary gland passes the message on to the testes. These communications happen through chemicals and hormones in the bloodstream.
Several large cohort studies have disclosed the trajectories of sex steroids changes overtime in men and their clinical significance. In men the slow, physiological decline of serum testosterone T with advancing age overlaps with the clinical condition of overt, pathological hypogonadism. In addition, the increasing number of comorbidities, together with the high prevalence of chronic diseases, all further contribute to the decrease of serum T concentrations in the aging male. For all these reasons both the diagnosis of late-onset hypogonadism LOH in men and the decision about starting or not T replacement treatment remain challenging. At present, the biochemical finding of T deficiency alone is not sufficient for diagnosing hypogonadism in older men. Coupling hypogonadal symptoms with documented low serum T represents the best strategy to refine the diagnosis of hypogonadism in older men and to avoid unnecessary treatments. Aging is associated with changes in the physiological functioning of the endocrine system.
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The numerous claims and conflicting reports concerning treatment with male sex hormone make it desirable to define its use more precisely. The testis consists essentially of two parts: 1 the seminiferous tubules, the most important function of which is to produce spermatozoa, and 2 the interstitial cells of Leydig, the most important function of which is to produce male sex hormone. On the production of the male sex hormone depends the development of secondary sex characteristics, namely the growth of the penis, scrotum, prostate, seminal vesicles, epididymis, vas deferens, body hair, beard, pitch of the voice and, to some extent, skeletal growth, including the contour of the body.
Hormones are natural substances made by the glands and organs of the hormone system. Hormones act as messengers and carry signals between one part of the body to another. There are many different types of hormones. They move through the body in the blood to certain cells and organs.